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ommended screening dilutions for each manufacturer.
Study results are summarized in table 2.
The patients positive in the "other connective tissue
disease" categories on Immuno Concepts substrate
had temporal arthritis (1), undifferentiated connective
tissue disease (1), polymyositis (2), monoarthritis (2),
TABLE 1
Diagnosis
Abnormal Population
(Over 4,500 Sera Tested):
Systemic lupus erythematosus
Rheumatoid arthritis
Mixed connective tissue disease
Progressive systemic sclerosis-diffuse
Progressive systemic sclerosis-CREST
Juvenile rheumatoid arthritis
Systemic
Polyarticular
Pauciarticular-B27+
DM/PM
Vasculitis
Normal Population (Over 9,000 Sera Tested):
20-60 Years
70-80 Years
Abbreviations: S = Speckled, H = Homogenous, P = Peripheral, N = Nucleolar, ACA = anti-Centromere
TABLE 2
Diagnostic
Population pathologique
(plus de 4 500 échantillons de sérum testés) :
Lupus érythémateux disséminé
DIAGNOSIS
Polyarthrite rhumatoïde
Connectivité mixte (MCTD)
SLE
Sclérodermie généralisée évolutive - diffuse
Sclérodermie généralisée évolutive - CREST ACA
MCTD / overlap
Arthrite rhumatoïde juvénile
Disséminée
Raynaud's PSS-CREST
Polyarticulaire
Pauciarticulaire B27+
RA
DM/PM
Vascularite
JRA
Population saine
Other connective tissue disease
(plus de 9 000 échantillons de sérum testés) :
20-60 ans
Hospitalized controls
70-80 ans
Normal controls
Abréviations : M = Moucheté, H = Homogène, P = Périphérique, N = Nucléolaire, ACA = anti-Centromère
Diagnosi
Diagnostic
Popolazione anormale (oltre 4.500 sieri analizzati)
Lupus eritematoso sistemico
LED
Artrite reumatoide
MCTD / chevauchement
Malattia mista del tessuto connettivo
Sclerosi sistemica progressiva-diffusa
Raynaud PSS-CREST
Sclerosi sistemica progressiva-CREST
Artrite reumatoide giovanile
Polyarthrite rhumato
Sistemica
Poliarticolare
Arthrite rhumato
Pauciarticolare-B27+
DM/PM
Autres collagénoses
Vasculite
Popolazione normale (oltre 9.000 sieri analizzati)
Sujets hospitalisés
20-60 anni
70-80 anni
Sujets sains
Abbreviazioni: S = Puntegtiato, H = Omogeneo, P = Periferico, N = Nucleolare, ACA = anti-Centromero
Diagnosi
Diagnóstico
SLE
Población anómala (más de 4.500 sueros evaluados):
MCTD / coincidenti
Lupus eritematoso sistémico
Artritis reumatoide
PSS-CREST di Raynaud
Enfermedad mixta del tejido conjuntivo
Esclerosis sistémica progresiva-difusa
RA
Esclerosis sistémica progresiva-CREST
Artritis reumatoide juvenil
JRA
Sistémica
Poliarticular
Altre malattie del tessuto connettivo
Pauciarticular-B27+
DM/PM
Controlli ospedalizzati
Number
of
Patients
23
7
17
2
4
9
11
24
Nombre
Patients
23
17
ï
de
ï
de juvénile
11
24
Numero
pazienti
23
17
11
polyarthritis (3), and not further classifiable.
The hospitalized controls with positive ANAs on Immuno
Concepts substrate had diabetes (2), unclassifiable
arthritis (3), hypothyroidism (1), and immune complex
renal disease (1) which did not meet criteria for diag-
nosis of SLE.
Pattern
Segregation
S,P+H,H,P
S,H
S
S,N
ACA
S
S
-
S
S
S
S
Motif
Ségrégation
Immuno
Concepts
Positives
M,P+H,H,P
1:40
M,H
M
23
M,N
ACA
7
M
17
M
-
2
M
M
4
9
M
7
M
1
Positivité
Immuno
Pattern
de
Concepts
Isolamento
1:40
S,P+H,H,P
23
S,H
7
S
7
S,N
17
ACA
2
2
S
S
4
4
-
S
9
9
S
7
S
S
1
Immuno
Concepts
di
Positivi
Tipos de
1:40
patrón
23
7
7
S,P+H,H,P
S,H
17
S
S,N
2
2
ACA
4
4
S
S
9
9
-
7
S
7
%
Positive
93
40
99
85
93
14
13
0
25
20
2
3.5
%
Positif
KB
Mouse
Cells
Kidney
Positives
Positives
93
1:20
1:20
40
99
22
21
85
93
6
4
14
16
7
13
0
2
0
25
20
4
3
9
6
2
3
2
3.5
1
0
Positivité
Positivité
Cellules
Reins de
%
KB
Souris
Positivo
1:20
1:20
93
22
21
40
6
99
4
85
16
7
93
2
0
14
13
4
3
0
25
9
6
20
3
2
2
3.5
1
0
Positivi
Topo
Cellule
Rene
KB
Positivi
%
1:20
1:20
Positivo
22
21
6
4
93
40
16
7
99
85
2
0
93
4
3
14
13
9
6
0
25
3
2
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