Sartorius Stedim Sartocon Bedienungsanleitung Seite 8

8 Safety instructions
Retentate backpressure is defined as follows:
Permeate pressure is higher than the Retentate pressure
P > P ;
perm ret
P = P - P .
back perm ret
Hydrostatic pressure on the permeate side (height and the inner diameter of the
filtrate tubing) has an impact on backpressure.
Please make sure that the maximum backpressure is never exceeded.
Note
This has to be distinguished from Transmembrane Pressure.
− Transmembrane pressure (TMP):
TMP = [(p + p )/2] – p
feed ret perm
− and from Differential Pressure:
Δp = p – p
feed ret
Feed pressure (p ) and retentate pressure (
feed
Permeate pressure (p ) is the average pressure on the permeate side, measureable
perm
with a gauge.
If the possibility of crystalline particles entering the cassettes cannot be
completely ruled out (for example, due to abrasion in the pumps), a prefilter
must be used.
Make sure that crystallization caused by changes in temperature or
concentration cannot occur during operation or storage.
Do not combine cassettes that have a different feed inlet design.
Sartocon cassettes have alternating oval and round ports.
Install the filter cassettes in the appropriate holding device only. You will need
either a Sartocon Slice, Sartocon
®
depending on the type and amount of filter cassette you plan to use.
If you wish to use holding devices supplied by other manufacturers, you may
need to apply a different torque pressure when installing cassettes.
To avoid damaging the cassettes, please contact our application specialist.
Make sure that the correct crossflow conditions are maintained during filtration.
Otherwise, the flux rate of the filter cassettes will decrease rapidly during filtration
under static conditions (dead-ended filtration) [Æ Chapter "5.7 Filtration",
page 21).
The temperature of the retentate must not exceed that given for continuous
operation, which is listed in the "Specifications." During crossflow filtration,
the temperature will increase over time because the kinetic energy of the pump
is transferred to the liquid undergoing filtration. If the temperature increases
beyond that indicated in the "Specifications," the pressure resistance of the
crossflow system will decrease.
), both measureable with a gauge.
pret
2 plus or a SARTOFLOW
® ®
holding device,