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22
Start up of cassettes
We recommend the following cleaning agents and conditions for the various
membrane materials. This table gives suggested procedures only; requirements
may vary in individual cases:
Cleaning agent
Concen tration
Polyethersulfone and
1 N
Hydrosart
Sodium
®
hydroxide
Phosphoric acid
2%
Adjust the following pressures:
Microfilter cassettes:
Polythersulfone MF
p
= 29 psi|2.0 bar|200 kPa
inlet
p
= 0 psi|0 bar|0 kPa
ret
Hydrosart
MF
p
= 29 psi|2.0 bar|200 kPa
®
inlet
p
= 0 psi|0 bar|0 kPa
ret
Recirculate cleaning solution with permeate valves closed for 60 minutes.
Repeat with fresh cleaning solution and permeate valve open. Repeat as required.
Ultrafilter cassettes:
Polythersulfone UF
p
= 29 psi|2.0 bar|200 kPa
inlet
p
= 0 psi|0 bar|0 kPa
ret
Hydrosart
®
UF
p
= 14.5 psi|1.0 bar|100 kPa
inlet
p
= 0 psi|0 bar|0 kPa
ret
Recirculate cleaning solution with permeate valves closed for 60 minutes.
Repeat with fresh cleaning solution and permeate valve open. Repeat as required.
Flush the filter cassettes with purified water as described in [Æ Chapter "5.3 Rinsing
Cassettes", page 13]. Determine the flux rate of the cleaned cassette as described in
[Æ Chapter "5.5 Determining Clean Water Flux for Filter Cassettes (CWF)",
page 15]. Compare results with the previously determined clean water flux (CWF).
It is normal to have a greater drop in clean water flux rate after the first processing
and complete cleaning. Good cleaning practice will result in less water flux deviation.
If the flux rate remains below this level after further cleaning attempts, please
contact your local Sartorius Stedim application specialist.
Generally, the Sartorius Stedim Biotech product and material limitations, especially
regarding pH and temperature stability of the membranes and cassettes, must be
adhered to.
Detection Method of NaOH cleaning agent clearance:
− Neutral pH effluent in both retentate and permeate.
− Conductivity.
pH
Time
Temperature
[min]
[°C]
14
60
50
1.3
30
50
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